In the wake of a series of tragic events impacting public health in the United States, the Department of Health and Human Services Centers for Disease Control and Prevention and the Department of Homeland Security have attempted to facilitate information sharing across public health and homeland security organizations. Data collected as part of a national assessment of law enforcement and homeland security information sharing, funded by the National Institute of Justice, indicate such efforts to date have been helpful in establishing a foundation for information sharing, yet fall short of creating mechanisms by which tangible information sharing can occur. Recent initiatives to remedy this shortcoming are presented and recommendations for further success are discussed.