The drainage of pancreatic exocrine secretions following pancreas transplantation is an evolving area of surgical practice. We describe a new technique applying a 55 mm Linear Cutting Stapler (LCS) to create the duodenoenterostomy for enteric drainage of the pancreas transplant. Twenty simultaneous pancreas and kidney transplantations performed between April 2005 and March 2006 were reviewed. Using a prospective database and chart review, complications and outcome related to the new technique of exocrine drainage were described. During this 12 month period, 19 of 20 consecutive simultaneous pancreas and kidney transplantations have been performed using the linear cutting stapler techinque. No complications relating to the enteric anastomosis have been demonstrated. In our initial experience, use of the LCS is both safe and easy to perform.