Cell Press, Current Biology, 19(23), p. R880-R883, 2013
DOI: 10.1016/j.cub.2013.08.030
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The mechanism of action of the mTOR inhibitor rapamycin is poorly understood and why certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-specific analysis of mTORC1 substrates now suggests that the sequence composition of a phosphorylation site determines whether it is sensitive to rapamycin and starvation.