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Nature Research, Nature Methods, 9(9), p. 897-900, 2012

DOI: 10.1038/nmeth.2130

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A mouse model to identify cooperating signaling pathways in cancer

Journal article published in 2012 by Monica Musteanu, Rainer Zenz, Jasmin Svinka, Leander Blaas ORCID, Thomas Hoffmann, Beatrice Grabner, Hans-Peter Kantner, Mathias Müller, Dagmar Stoiber, Thomas Kolbe, Daniel Schramek ORCID, Thomas Rülicke, Richard Moriggl ORCID, Lukas Kenner ORCID, Josef Martin Penninger and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.