In the parabolic trough concentrator with tube receiver system, the heat transfer fluid flowing through the tube receiver can induce high thermal stress and deflection. In this study, the eccentric tube receiver is introduced with the aim to reduce the thermal stresses of tube receiver. The ray–thermal–structural sequential coupled numerical analyses are adopted to obtain the concentrated heat flux distributions, temperature distributions and thermal stress fields of both the eccentric and concentric tube receivers. During the sequential coupled numerical analyses, the concentrated heat flux distribution on the bottom half periphery of tube receiver is obtained by Monte-Carlo ray tracing method, and the fitting function method is introduced for the calculated heat flux distribution transformation from the Monte-Carlo ray tracing model to the CFD analysis model. The temperature distributions and thermal stress fields are obtained by the CFD and FEA analyses, respectively. The effects of eccentricity and oriented angle variation on the thermal stresses of eccentric tube receiver are also investigated. It is recommended to adopt the eccentric tube receiver with optimum eccentricity and 90° oriented angle as tube receiver for the parabolic trough concentrator system to reduce the thermal stresses.