In this paper a framework for Sharing Knowledge and Integrated Information in Radiotherapy (SKIIR) for medical physicists involved in Therapeutic Radiological Physics is discussed. The proposed SKIIR is mainly designed for sharing knowledge based on specific cases of treating patients with cancer. Integrated Information and Knowledge are captured for storing knowledge and medical information related to the specific cases of interest, in any useful form and format, for the medical physicists. Various patient cases’ descriptions and related documents of primary interest for the medical physicists are stored and organized for future use in a multimedia library including short descriptions, radiotherapy planning, ultrasound, CT and MRI images, statistical information, bibliography, discharge letters, etc. Codification of knowledge and preservation of anonymity is also discussed.