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Elsevier, Cancer Letters, 1-2(260), p. 209-215

DOI: 10.1016/j.canlet.2007.11.002

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Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer

Journal article published in 2008 by Tess V. Clendenen, Alan A. Arslan ORCID, Karen L. Koenig, Kerstin Enquist, Isaac Wirgin, Åsa Ågren, Asa Agren, Annekatrin Lukanova, Hubert Sjodin, Anne Zeleniuch-Jacquotte ORCID, Roy E. Shore, Göran Hallmans, Paolo Toniolo, Eva Lundin
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D. The associations between four common VDR polymorphisms (BSMI, APAI, TAQI, and FOKI) and risk of epithelial ovarian cancer (EOC) were assessed in a case-control study nested within two prospective cohorts. One hundred seventy incident cases of EOC and 323 individually matched controls were genotyped. Overall, no associations were observed in genotype analyses. Haplotypes combining three SNPs in high linkage disequilibrium (BSMI, APAI, and TAQI) were also not associated with risk. These observations do not support a role for BSMI, APAI, TAQI, and FOKI polymorphisms in epithelial ovarian cancer in a predominantly Caucasian population.