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Oxford University Press (OUP), Human Molecular Genetics, 21(18), p. 4195-4203

DOI: 10.1093/hmg/ddp365

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Common and different genetic background for rheumatoid arthritis and coeliac disease.

Journal article published in 2009 by Marieke J. H. Coenen ORCID, Gosia Trynka, Sandra Heskamp, Barbara Franke ORCID, Cleo C. van Diemen, Joanna Smolonska, Miek van Leeuwen, C. C. van Diemen, Elisabeth Brouwer, Miek van Leeuwen, Marike H. Boezen, Dirkje S. Postma, Mathieu Platteel, Pieter Zanen ORCID, Jan-Willem W. J. Lammers and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Recent genome-wide association studies (GWAS) have revealed genetic risk factors in autoimmune and inflammatory disorders. Several of the associated genes and underlying pathways are shared by various autoimmune diseases. Rheumatoid arthritis (RA) and coeliac disease (CD) are two autoimmune disorders which have commonalities in their pathogenesis. We aimed to replicate known RA loci in a Dutch RA population, and to investigate whether the effect of known RA and CD risk factors generalize across the two diseases. We selected all loci associated to either RA or CD in a GWAS and confirmed in an independent cohort, with a combined P-value cut-off P