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The Royal Society, Proceedings of the Royal Society B: Biological Sciences, 1500(269), p. 1555-1561, 2002

DOI: 10.1098/rspb.2002.2074

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Going nuclear: gene family evolution and vertebrate phylogeny reconciled.

Journal article published in 2002 by James A. Cotton ORCID, Roderic D. M. Page
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Gene duplications have been common throughout vertebrate evolution, introducing paralogy and so complicating phylogenetic inference from nuclear genes. Reconciled trees are one method capable of dealing with paralogy, using the relationship between a gene phylogeny and the phylogeny of the organisms containing those genes to identify gene duplication events. This allows us to infer phylogenies from gene families containing both orthologous and paralogous copies. Vertebrate phylogeny is well understood from morphological and palaeontological data, but studies using mitochondrial sequence data have failed to reproduce this classical view. Reconciled tree analysis of a database of 118 vertebrate gene families supports a largely classical vertebrate phylogeny.