Cancer and related lifestyle diseases are on the increase across Asia and already account for over half the disease-associated mortality in the vast majority of the included countries. An understanding of the epidemiology is therefore of paramount importance. In addition, given the immensity of the problem, cooperation among all the interested parties is of the essence. The present series of reviews were complied with the aim of promoting better comprehension and interaction, focusing on cancer prevalence and the underlying risk and preventive factors in Asia. Data from Cancer Incidence in Five Continents and Globocan 2002, published by the International Agency for Research on Cancer, as well as various other cancer registry sources, were thus married with research information in the public domain, accessible through PubMed. It is hoped that the comprehensive approach adopted for the different regions will help bring together all of the Asian community of individuals involved in cancer epidemiology and control and contribute to establishment of Asian networks for collaborative research. The major players and the overall picture for cancer control are covered in the present overview. Further details are then provided in seven separate regional reviews: for North-Western and Central Asia; South-West Asia; South Asia; Mainland South-East Asia; Peninsular and Island South-East Asia, the Pacific; and North-East Asia. The final section covers possible organ-based strategies for cancer control and, lastly, an Appendix has been included listing research institutes and staff in Asia to facilitate contacts between interested individuals.