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PAGEpress, Oncology Reviews, 1(6), p. 11, 2012

DOI: 10.4081/oncol.2012.e11

PAGEpress, Oncology Reviews, p. e11, 2012

DOI: 10.4081/oncol.2012.174

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A role of active brown adipose tissue in cancer cachexia?

Journal article published in 2012 by Emiel Beijer, Wouter van Marken Lichtenbelt, Miel Wouters, Janna Schoenmakers, Fons Kessels, Dingemans Am, Anne-Marie Dingemans, Guy Vijgen ORCID, Patrick Schrauwen ORCID, Jaap Teule, Boudewijn Brans
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT). Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energetic pathways. White, brown and socalled brite adipose fat seem to be able to trans-differentiate into each other, emphasizing the dynamic nature of fat tissue for metabolism. Human and animal data in cancer cachexia to date provide some evidence for BAT activation, but its quantitative impact on energy expenditure and weight loss is controversial. Prospective clinical studies can address the potential role of BAT in cancer cachexia using <sup>18</sup>F-fluorodeoxyglucose positron emission tomography-computed tomography scanning, with careful consideration of co-factors such as diet, exposure to the cold, physical activity and body mass index, that all seem to act on BAT recruitment and activity.