Published in
Royal Society of Chemistry, Chemical Communications, 17(47), p. 4992, 2011
DOI: 10.1039/c0cc04960c
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DOTASQ as a prototype of nature-inspired G-quadruplex ligand
Journal article published in 2011 by
Loic Stefan,
Aurore Guédin,
Samir Amrane 
,
Nicole Smith,
Franck Denat,
Jean-Louis Mergny ,
David Monchaud
,
Nicole Smith,
Franck Denat,
Jean-Louis Mergny ,
David Monchaud
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Abstract
DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).