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Taylor and Francis Group, RNA Biology, 9(9), p. 1161-1166, 2012

DOI: 10.4161/rna.21630

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Armless mitochondrial tRNAs in Enoplea (Nematoda)

Journal article published in 2012 by Frank Jühling, Joern Pütz, Florentz Catherine, Peter F. Stadler ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The mitochondrial genome of metazoan animal typically encodes 22 tRNAs. Nematode mt-tRNAs normally lack the T-stem and instead feature a replacement loop. In the class Enoplea, putative mt-tRNAs that are even further reduced have been predicted to lack both the T-and the D-arm. Here we investigate these tRNA candidates in detail. Three lines of computational evidence support that they are indeed minimal functional mt-tRNAs: (1) the high level of conservation of both sequence and secondary structure, (2) the perfect pres-ervation of the anticodons, and (3) the persistence of these sequence elements throughout several genome rearrange-ments that place them between different flanking genes.