The coffee leaf rust (Hemileia vastatrix) disease causes serious losses in coffee production and quality, with a huge depreciation of marketing values. The reduction of availability of effective approved fungicides, due to health and environmental concerns, makes it necessary to intensify research for the development of novel, effective and sustainable disease control solutions, such as the resistance inducers. With the aim of understanding the mechanisms that are behind the disease control capacity of the resistance inducers " Greenforce Cuca " and Bion® we made a proteomic analysis of the C. arabica leaf responses upon the treatments. The leaf proteins were extracted with trichloroacetic acid in acetone and separated by two-dimensional gel electrophoresis followed by colloidal Coomassie blue staining and image analysis. About thirty five spots showed a statistical significant variation in abundance due to the treatments. The proteins identified by high-performance liquid chromatography-mass spectrometry (LC-MS/MS) followed by homology search in ESTs coffee databases, are mostly involved in the photosynthetic process (photochemical and carbon reactions) and its regulation and responses to stimulus/stress. The functional characterization of these proteins is ongoing and the metabolic processes involved in coffee induced resistance against the fungus will be further analysed.