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American Society for Microbiology, Journal of Virology, 24(85), p. 13443-13447, 2011

DOI: 10.1128/jvi.05615-11

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Vaginal Langerhans Cells Nonproductively Transporting HIV-1 Mediate Infection of T Cells

Journal article published in 2011 by Lamar Ballweber, Barry Robinson, Allison Kreger, Michael Fialkow, Gretchen Lentz, M. Juliana McElrath, M. Juliana McElrath, Florian Hladik ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4 + T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle.