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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (10), p. 897-901, 2014

DOI: 10.3762/bjoc.10.87

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Clean and fast cross-coupling of aryl halides in one-pot

Journal article published in 2014 by Valerica Pandarus, Geneviève Gingras, François Béland, Rosaria Ciriminna, Mario Pagliaro ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Unsymmetrically coupled biaryls are synthesized in high yield starting from different aryl bromides and bis(pinacolato)diboron by carrying out the Miyaura borylation reaction followed by the Suzuki–Miyaura reaction in the same reaction pot over 1–2 mol % SiliaCat DPP-Pd. The SiliaCat DPP-Pd catalyst is air-stable and the method does not require the use of inert conditions. The use of non-toxic isopropanol or 2-butanol as reaction solvent further adds to the environmental benefits of this new green synthetic methodology.