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Elsevier, Saudi Journal of Biological Sciences, 1(24), p. 11-14, 2017

DOI: 10.1016/j.sjbs.2015.08.006

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Analysis of anti-bacterial and anti oxidative activity of Azadirachta indica bark using various solvents extracts

Journal article published in 2017 by Raid Al Akeel, Ayesha Mateen, K. Janardhan, V. C. Gupta
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Herbal medications have been used for relief of symptoms of disease. Regardless of the great advances observed in current medicine in recent decades, plants still make an significant contribution to health care. An alarming increase in bacterial strains resistant to a number of antimicrobial agents demands that a renewed effort be made to seek antibacterial agents effective against pathogenic bacteria resistant to or less sensitive to current antibiotics .Anti-bacterial activity of Azadirachta indica stem bark was tested against pathogenic Salmonella paratyphi and Salmonella typhi using various solvent extracts. The in vitro anti-bacterial activity was performed by agar well diffusion method and the results were expressed as the average diameter of zone of inhibition of bacterial growth around the well. The Ethanol and methanol extracts showed better anti-bacterial activity with zone of inhibition (20-25mm) when compared with other tested extracts and standard antibiotic Erythromycin(15 mcg) with zone of inhibition (13-14mm). Using Fisher’s exact test significance difference was found between two salmonella strains sensitivity pattern against tested extracts (P</=0.035). The extracts of Azadirachta indica stem bark also exhibited significant antioxidant activity, thus establishing the extracts as an antioxidant.The results obtained in this study gives some scientific support to the Azadirachta indica stem bark for further investigation of compounds and in future could be used as drug.