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American Chemical Society, Journal of Natural Products, 6(75), p. 1228-1230, 2012

DOI: 10.1021/np3002942

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Lasionectrin, a Naphthopyrone from a Lasionectria sp.

Journal article published in 2012 by Noureddine El Aouad ORCID, Guiomar Pérez-Moreno, Paula Sánchez, Juan Cantizani, Francisco Javier Ortiz-López ORCID, Jesús Martín, Víctor González-Menéndez, Luis M. Ruiz-Pérez, Dolores González-Pacanowska, Francisca Vicente, Gerald Bills, Fernando Reyes
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 μM.