Published in
Royal Society of Chemistry, Analytical Methods, 5(7), p. 1667-1671, 2015
DOI: 10.1039/c4ay02618g
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Detection of Interaction between Protein Trytophan Residues and Small or Macromolecular Ligands by Synchrotron Radiation Magnetic Circular Dichroism
Journal article published in 2014 by
Ashley J. Hughes 
,
Timothy R. Rudd,
Gareth S. A. Wright,
David Garth Fernig ,
Giuliano Siligardi,
Edwin A. Yates
,
Timothy R. Rudd,
Gareth S. A. Wright,
David Garth Fernig ,
Giuliano Siligardi,
Edwin A. Yates
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Abstract
Presented herein is a novel method for the detection of tryptophan-ligand interactions utilising magnetic circular dichroism. Two examples are presented, one a small molecule and another, a large polysaccharide, heparan sulfate. These data are also the first reported example of a Trp:glycosaminoglycan interaction shown by magnetic circular dichroism.