Heterointerfaces in manganite-based heterostructures in either layered or vertical geometry are considered as one of the keys to manipulate and improve the magnetotransport properties. Instead of using the spin polarized tunneling across the interface, a unique approach based on the magnetic exchange coupling along the vertical interface to control magnetotransport properties has been demonstrated. By coupling ferromagnetic La0.7Sr0.3MnO3 and antiferromagnetic NiO in an epitaxial vertically aligned nanocomposite (VAN) architecture, a dynamic and reversible switch of the resistivity between two distinct exchange biased states has been achieved. This study explores the use of vertical interfacial exchange coupling to tailor magnetotransport properties, which may serve as a viable route for spintronic applications.