New Findings• What is the topic of this review? This short review examines how advanced imaging can be used to assess remodelling of the heart non‐invasively following myocardial infarction in murine experimental models. • What advances does it highlight? We review recent advances in the application of high‐resolution ultrasound, magnetic resonance imaging (MRI) and fluorescence molecular tomography (FMT), as well as positron emission tomography (PET) and single‐photon excitation computed tomography (SPECT) for assessment of processes involved in infarct healing, e.g. inflammation, as well as global structural and functional analysis.