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Oxford University Press (OUP), The Journal of Infectious Diseases, 5(193), p. 698-702

DOI: 10.1086/499820

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Repeat-Region Polymorphisms in the Gene for the Dendritic Cell–Specific Intercellular Adhesion Molecule-3–Grabbing Nonintegrin–Related Molecule: Effects on HIV-1 Susceptibility

Journal article published in 2006 by Huanliang Liu, Mary Carrington, Chunhui Wang, Sarah Holte, Jean Lee, Benjamin Greene, Florian Hladik ORCID, David M. Koelle, Anna Wald, Kyoko Kurosawa, Charles R. Rinaldo, Connie Celum, Roger Detels, Lawrence Corey, M. Juliana McElrath and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In 1716 individuals--801 human immunodeficiency virus (HIV)-1-seropositive individuals, 217 high-risk HIV-1-seronegative individuals, and 698 general HIV-1-seronegative individuals--from a Seattle cohort and a Multicenter AIDS Cohort Study cohort, the association between HIV-1 susceptibility and repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule (DC-SIGNR) was investigated; 16 genotypes were found in the DC-SIGNR repeat region. The DC-SIGNR homozygous 7/7 repeat was found to be associated with an increased risk of HIV-1 infection (17.5% in high-risk HIV-1-seronegative individuals vs. 28.5% in HIV-1-seropositive individuals; P=.0015), whereas the DC-SIGNR heterozygous 7/5 repeat tended to be correlated with resistance to HIV-1 infection (35.5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1.