Elsevier, Bioorganic and Medicinal Chemistry
DOI: 10.1016/s0968-0896(02)00316-4
Elsevier, Bioorganic and Medicinal Chemistry, 10(11), p. 2263-2268
DOI: 10.1016/s0968-0896(03)00111-1
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The synthesis of O-propynyloximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone, containing several pyrazole frameworks is described, together with their muscarinic receptor affinities. Compounds derived from N-methylpiperidinone or 3-tropinone and N-(4-methoxybenzyl)- or N-(2,4,6-trimethylbenzoyl)pyrazole showed moderate activity for muscarinic receptors in the rat central nervous system. A semi-empirical AM1 calculation has shown that the O-[(benzoyl-pyrazolyl)propynyl]-oximes of tropinone fit a previously described muscarinic pharmacophoric model, revealing structural features useful for the development of new muscarinic agents.