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Nature Research, Nature Genetics, 9(43), p. 825-827

DOI: 10.1038/ng.879

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Common variation at 10p12.31 near MLLT10 influences meningioma risk

Journal article published in 2011 by Sara E. Dobbins, Peter Broderick ORCID, Beatrice Melin, Maria Feychting, Christoffer Johansen ORCID, Ulrika Andersson, Thomas Brannstrom, Thomas Brännström, Johannes Schramm, Bianca Olver, Amy Lloyd, Yussanne P. Ma, Fay J. Hosking, Stefan Lönn, Anders Ahlbom and other authors.
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Abstract

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.