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Centers for Disease Control and Prevention, Emerging Infectious Diseases, 11(13), p. 1769-1772, 2007

DOI: 10.3201/eid1311.070222

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Viral Load as Predictor of Crimean-Congo Hemorrhagic Fever Outcome

Journal article published in 2007 by Darja Duh, Ana Saksida, Miroslav Petrovec, Salih Ahmeti, Iusuf Dedushaj, Marcus Panning, Christian Drosten, Tatjana Avšič-Županc ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We used quantitative real-time reverse transcription– PCR to measure viral load in serum from 24 patients in Kosovo who had acute Crimean-Congo hemorrhagic fever. Viral load correlated with clinical disease and antibodies and could be used as a predictor of disease outcome. Crimean-Congo hemorrhagic fever (CCHF), caused by CCHF virus, is a potentially fatal infection in Africa, Asia, Eastern Europe, and the Middle East. CCHF virus is transmitted to humans by bites of Ixodid ticks and from person to person by contact with blood or blood-containing body fluids. Therefore, nosocomial and intrafamiliar cases are frequently reported in CCHF outbreaks (1). CCHF can be treated with ribavirin, but the decision about which CCHF patients should be given the drug may be difficult (2,3). Classification of patients according to criteria of disease