Springer Verlag, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 1-2(69), p. 149-155
DOI: 10.1007/s10847-010-9825-1
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Accidental or intentional drug toxicity in humans and animals is a major concern and the search for detoxificant agents is a challenge. Pyrrolizidine-producing forages are a threat not only to livestock, but also to humans as a consequence of food contamination. Supramolecular systems are promising as detoxificant agents by decreasing the bioavailability of toxic compounds in biological envi-ronment. Cyclodextrin and calix[n]arenes are well known hosts for a variety of molecules and/or ions. Surprisingly, only few studies describe the potential of calix[n]arenes as host for toxic molecules. This study focused on the use of NMR techniques as tools for the investigation of the interactions between p-sulfonic acid calix[6]arene and ret-ronecine, a toxic pyrrolizidine alkaloid.