Published in
Wiley, Magnetic Resonance in Chemistry, 7(50), p. 515-522, 2012
DOI: 10.1002/mrc.3830
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NMR spectroscopic characterization of new 2,3-dihydro-1,3,4-thiadiazole derivatives: NMR Studies of 2,3-dihydro-1,3,4-thiadiazole derivatives
,
Miguel A. Gallo,
Antonio Espinosa,
Antonio Entrena,
M. Encarnación Camacho
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Abstract
The (1) H and (13) C NMR resonances of twenty-seven 2,2-dimethyl-5-(2-nitrophenyl-5-substituted)-2,3-dihydro-1,3,4-thiadiazoles, and twenty-seven 3-acyl-5-(2-amino-5-substituted)-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazoles were assigned completely using the concerted application of one-dimensional and two-dimensional experiments (DEPT, HMQC and HMBC). NOESY experiments, X-ray crystallography and conformational analysis confirm the preferred conformation of these compounds.