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Wiley, Journal of Inorganic and General Chemistry, 8-9(639), p. 1590-1597, 2013

DOI: 10.1002/zaac.201300054

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Osmium-Nitrosyl Complexes with Glycine, Picolinic Acid, ­L-Proline andD-Proline: Synthesis, Structures and Antiproliferative Activity

Journal article published in 2013 by Anatolie Gavriluta, Maria Novak, Jean Bernard Tommasino, Samuel M. Meier ORCID, Michael A. Jakupec ORCID, Dominique Luneau, Vladimir B. Arion
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This paper is available in a repository.

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Abstract

The reactions of [Os(NO)Cl5]2– with glycine (GlyH), picolinic acid (PicoH), L-proline (L-ProH) and D-proline (D-ProH) afforded four novel complexes of the general formula [Os(NO)Cl3(AA)]–, where AA = Gly, Pico, L-Pro and D-Pro, respectively. X-ray diffraction studies have revealed that in all cases the same isomer type from three theoretically possible, has been isolated, namely mer(Cl), trans(NO, O)-[Os(NO)Cl3(AA)]–. Spectroscopic and electrochemical properties, behavior in aqueous solution and antiproliferative activity in three human cancer cell lines are also reported.