1.Advancing the field of ecology relies on understanding generalities and developing theories based on empirical and functional relationships that integrate across organismal to global spatial scales and span temporal scales. Significant advances in predicting responses of ecological communities to globally-extensive anthropogenic perturbations, for example, require understanding the role of environmental context in determining outcomes, which in turn requires standardized experiments across sites and regions. Distributed collaborative experiments can lead to high-impact advances that would otherwise be unachievable. 2.Here, we provide specific advice and considerations relevant to researchers interested in employing this emerging approach using as a case study our experience developing and running the Nutrient Network, a globally-distributed experimental network (currently >75 sites in 17 countries) that arose from a grassroots, cooperative research effort. 3.We clarify the design, goals, and function of the Nutrient Network as a model to empower others in the scientific community to employ distributed experiments to advance our predictive understanding of global-scale ecological trends and responses. 4.Our experiences to date demonstrate that globally-distributed experimental science need not be prohibitively expensive or time-consuming on a per capita basis and is not limited to senior scientists or countries where science is well-funded. While distributed experiments are not a panacea for understanding ecological systems, they can substantially complement existing approaches. This article is protected by copyright. All rights reserved.