Published in
Royal Society of Chemistry, Chemical Communications, 13(51), p. 2559-2561
DOI: 10.1039/c4cc09056j
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The X-ray structure of the Primary Adducts formed in the Reaction between Cisplatin and Cytochrome c
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Abstract
In the present study, the interactions between cisplatin and cytochrome c are investigated. Based on high-resolution X-ray diffraction data, two monometalated species, i.e. cyt c-Pt(NH3)2 and cyt c-Pt(NH3)2Cl, are found to be the main adducts that form in the reaction between the protein and the drug. Both monodentate and bidentate platinum coordination to the protein is observed, with platinum binding either to Met65 or to Met65 and Glu61, simultaneously.