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Public Library of Science, PLoS ONE, 6(10), p. e0129817, 2015

DOI: 10.1371/journal.pone.0129817

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Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies

Journal article published in 2015 by Marco Deiana, Heidar-Ali Tajmir-Riahi, Katarzyna Matczyszyn ORCID, Julien Massin, Joanna Olesiak-Banska ORCID, Chantal Andraud, Marek Samoc
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications.