The isolation of 2D-materials is already a success for graphene, graphene oxide, boron nitride, few clays or metal chalcogenides, however despite some of them show very interesting physical properties, they lack of useful functionalities. Metal-Organic Frameworks (MOFs) are multifunctional materials showing a wide range of physical and chemical properties that can be structurally designed by suitable selection of their building-blocks. This strategy may allow the production of layers with a variety of useful electronic and molecular recognition functionalities. Herein we isolate 2D-MOF flakes with over hundreds of square microns area and an excellent control of the molecular thickness (from single up to ca. 50 layers). The samples exhibit photoluminescence and mechanical properties so good as to allow freestanding characterization of few layers flakes.