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Lippincott, Williams & Wilkins, Transplantation, 10(86), p. 1340-1348, 2008

DOI: 10.1097/tp.0b013e3181891d8b

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Endothelial Cells in Allograft Rejection

Journal article published in 2008 by Rafia S. Al Lamki, John R. Bradley ORCID, Jordan S. Pober
This paper is available in a repository.
This paper is available in a repository.

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Abstract

In organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection responses by presentation of alloantigen to circulating T cells; the development of inflammation and thrombosis; and as targets of injury and agents of repair.