A peculiar effect was observed that the oxidation behavior of antimony oxide prepared in presence of a weak permanent magnetic field is changed. Reactivity of alpha-Sb2O3 (senarmontite) towards oxidation is significantly enhanced after recirculating its suspension in a magneto hydrodynamic (MHD) system. This inspired the MHD synthesis of a molybdenum-vanadiumantimony mixed oxide with superior catalytic activity for selective partial oxidation of isobutane. Traditionally these mixed oxides are synthesized via sol-gel processes involving complexing agents and/or costly alkoxides. Here a new convenient way is presented to synthesize Mo-V-Sb mixed oxide catalysts departing from senarmontite (alpha-Sb2O3), ammonium heptamolybdate and ammonium vanadate. The MHD treated mixed oxide prepared from suspensions of Sb2O3 with Mo and V salts was evaluated in isobutane partial oxidation and compared with conventionally prepared catalysts. Improved performance was observed for MHD catalysts, with a peak methacrolein selectivity of 40 % and decreased COx selectivity as compared to a reference „slurry-type‟ catalyst. Although the MHD synthesis mechanism cannot yet be explained on a molecular level, it represents significant scientific and economical potential. This report is intended as an invitation to assist in formulating a molecular mechanism capable of explaining these observations.