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Elsevier, Biochimie, 1(90), p. 131-155, 2008

DOI: 10.1016/j.biochi.2007.07.011

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Targeting telomeres and telomerase

Journal article published in 2008 by Anne De Cian, Laurent Lacroix ORCID, Céline Douarre, Nassima Temime-Smaali, Chantal Trentesaux, Jean-François Riou, Jean-Louis Mergny ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology.