Published in
Public Library of Science, PLoS ONE, 12(7), p. e52296, 2012
DOI: 10.1371/journal.pone.0052296
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Vaccination with L. infantum chagasi Nucleosomal Histones Confers Protection against New World Cutaneous Leishmaniasis Caused by Leishmania braziliensis
Journal article published in 2012 by
Marcia W. Carneiro,
Diego M. Santos,
Kiyoshi F. Fukutani,
Jorge Clarencio,
Jose Carlos Miranda,
Claudia Brodskyn,
Aldina Barral,
Manoel Barral-Netto 
,
Manuel Soto ,
Camila I. de Oliveira
,
Manuel Soto ,
Camila I. de Oliveira
This paper is made freely available by the publisher.
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Abstract
Background: Nucleosomal histones are intracellular proteins that are highly conserved among Leishmania species. After parasite destruction or spontaneous lysis, exposure to these proteins elicits a strong host immune response. In the present study, we analyzed the protective capability of Leishmania infantum chagasi nucleosomal histones against L. braziliensis infection using different immunization strategies.