1] Volcanic explosions or shallow earthquakes are known to trigger acoustic and gravity waves that propagate in the atmosphere at infrasonic speeds. At ionospheric heights, coupling between neutral particles and free electrons induces variations of electron density detectable with dual-frequency Global Positioning System (GPS) measurements. Using GPS data collected in the Caribbean, we identified an ionospheric perturbation after a major volcanic explosion at the Soufrière Hills Volcano (Montserrat, Lesser Antilles) on 13 July 2003. Spectral analysis reveals peaks centered at 1 and 4 mHz, similar to those in previous observations and consistent with theory, suggesting both gravity and acoustic wave components. We retrieve a horizontal velocity of $624 m/s for the acoustic component, which implies upward propagation at $33°, consistent with ray-tracing results. We model the acoustic wave using an N-wave pressure source at ground level combined with ray tracing to propagate the neutral pressure wave; this accounts for the dispersive characteristics of the atmosphere while conserving total acoustic energy. Plasma velocity is derived from neutral velocity using a finite difference solution of the magnetohydrodynamic momentum equation. The continuity equation for charge densities is used to compute corresponding electron density variations, which are then numerically integrated along satellite-to-receiver line of sights, simultaneously accounting for the satellite displacements. We minimize the misfit between observed and model waveforms to estimate a total acoustic energy release of 1.53 Â 10 10 J for the primary explosion event at Soufrière Hills Volcano associated with the peak dome collapse. This method can be applied to any explosion of sufficient magnitude, provided GPS data are available at near to medium range from the source.