Published in

Beilstein-Institut, Beilstein Journal of Organic Chemistry, (11), p. 147-154, 2015

DOI: 10.3762/bjoc.11.14

Links

Tools

Export citation

Search in Google Scholar

Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers

Journal article published in 2015 by Thorbjørn Terndrup Nielsen, Catherine Amiel, Laurent Duroux, Kim Lambertsen Larsen, Lars Wagner Städe, Reinhard Wimmer ORCID, Véronique Wintgens
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Orange circle
Preprint: archiving restricted
Upload
Orange circle
Postprint: archiving restricted
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Novel (S)-camptothecin–dextran polymers were obtained by “click” grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with β-cyclodextrin and β-cyclodextrin polymers were measured by isothermal titration calorimetry and fluorescence spectroscopy, showing no binding with β-cyclodextrin but high binding with β-cyclodextrin polymers. In aqueous solution nanoparticles were formed from association between the (S)-camptothecin–dextran polymers and the β-cyclodextrin polymers.