The Cueva del Angel archaeological site is an open-air sedimentary sequence, remnant of a collapsed cave and part of a karst complex. The faunal assemblage dominated by Equus ferus, large bovids and cervids has been subjected to intense anthropic actions reflecting selective predation. The fauna may be correlated with European faunistic associations of the end of the Middle Pleistocene to the beginning of the Upper Pleistocene. The Cueva del Angel lithic assemblage (dominated by non-modified flakes and abundant retouched tools with the presence of 46 handaxes) appears to fit well within the regional diversity of a well developed non-Levallois final Acheulean industry. A preliminary 230Th/234U age estimate, the review of the lithic assemblage and faunal evidence would favour a chronological positioning of the site in a period stretching from the end of the Middle Pleistocene to the beginning of the Upper Pleistocene (MIS 11–MIS 5). The Acheulean lithic assemblage found at the Cueva del Angel fits very well with the hypothesis of a continuation of Acheulean cultural traditions in the site, distinct from the contemporaneous uniquely Mousterian complexes witnessed in other parts of the Iberian Peninsula, and Western Europe.