Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity
Journal article published in 2005 by
M. Ramirez Osuna,
D. Chavez,
L. Hernandez,
E. Molins 
,
R. Somanathan,
G. Aguirre
,
R. Somanathan,
G. Aguirre
This paper is made freely available by the publisher.
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Abstract
Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds.