Published in
American Society of Hematology, Blood, 9(126), p. 1106-1117, 2015
DOI: 10.1182/blood-2014-12-618025
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- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts
Journal article published in 2015 by
Jerome Paggetti 
,
Franziska Haderk,
Martina Seiffert,
Bassam Janji,
Ute Distler,
Wim Ammerlaan,
Yeoun Jin Kim,
Julien Adam,
Peter Lichter,
Eric Solary ,
Guy Berchem,
Etienne Moussay
,
Franziska Haderk,
Martina Seiffert,
Bassam Janji,
Ute Distler,
Wim Ammerlaan,
Yeoun Jin Kim,
Julien Adam,
Peter Lichter,
Eric Solary ,
Guy Berchem,
Etienne Moussay
This paper is made freely available by the publisher.
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Abstract
Key PointsCLL-derived exosomes are internalized by stromal cells, deliver functional microRNA and proteins, and activate key signaling pathways. Stromal cells exposed to CLL-derived exosomes demonstrate a CAF-like phenotype and secrete factors promoting CLL cell survival.