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Elsevier, Tetrahedron, 20(65), p. 3990-3997

DOI: 10.1016/j.tet.2009.03.033

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An 'inside-out' approach to suramin analogues

Journal article published in 2009 by Ross P. McGeary ORCID, Andrew J. Bennett, Quoc B. Tran, Johannes Prins, Benjamin P. Ross ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

An approach to the synthesis of suramin analogues has been realised, which avoids synthetic problems associated with conventional routes. The use of isobutyl ester protecting groups for sulfonic acids was crucial to the success of the strategy, because these were able to be cleanly deprotected with sodium iodide, yielding the sodium salts of the corresponding sulfonic acids. (C) 2009 Elsevier Ltd. All rights reserved.