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Oxford University Press, International Journal of Epidemiology, 6(42), p. 1862-1872, 2013

DOI: 10.1093/ije/dyt182

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Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction

Journal article published in 2013 by Brandon L. Pierce, Lin Tong, Maria Argos, Jianjun Gao, Farzana Jasmine, Shantanu Roy, Rachelle Paul-Brutus, Ronald Rahaman, Muhammad Rakibuz-Zaman, Faruque Parvez, Alauddin Ahmed, Iftekhar Quasem, Samar K. Hore, Shafiul Alam, Tariqul Islam and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Background Arsenic exposure through drinking water is a serious global health issue. Observational studies suggest that individuals who metabolize arsenic efficiently are at lower risk for toxicities such as arsenical skin lesions. Using two single nucleotide polymorphisms (SNPs) in the 10q24.32 region (near AS3MT) that show independent associations with metabolism efficiency, Mendelian randomization can be used to assess whether the association between metabolism efficiency and skin lesions is likely to be causal.