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Oxford University Press, Bioinformatics, 13(29), p. i80-i88, 2013

DOI: 10.1093/bioinformatics/btt243

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Hard-wired heterogeneity in blood stem cells revealed using a dynamic regulatory network model

Journal article published in 2013 by Nicola Bonzanni, K. Anton Feenstra, Abhishek Garg, K. Anton Feenstra ORCID, Judith Schütte, Sarah Kinston, Diego Miranda-Saavedra, Jaap Heringa, Ioannis Xenarios ORCID, Berthold Göttgens
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Motivation: Combinatorial interactions of transcription factors with cis-regulatory elements control the dynamic progression through successive cellular states and thus underpin all metazoan development. The construction of network models of cis-regulatory elements, therefore, has the potential to generate fundamental insights into cellular fate and differentiation. Haematopoiesis has long served as a model system to study mammalian differentiation, yet modelling based on experimentally informed cis-regulatory interactions has so far been restricted to pairs of interacting factors. Here, we have generated a Boolean network model based on detailed cis-regulatory functional data connecting 11 haematopoietic stem/progenitor cell (HSPC) regulator genes.