Chemical Society of Japan, Chemistry Letters, 7(28), p. 687-688, 1999
DOI: 10.1246/cl.1999.687
Full text: Unavailable
Enantioselective synthesis of a novel kind of optically active nucleoside analogues from natural malic acid is described. In the given nucleoside analogues the tetrahydrofuran ring is replaced by a pyrrolidinonyl ring bearing both a primary and a secondary hydroxy groups which could be useful for the preparation of novel oligonucleotides. Assay of the prepared nucleoside analogues showed non-activity against virus.