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Nature Research, Nature Chemical Biology, 3(5), p. 131-134, 2009

DOI: 10.1038/nchembio0309-131

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Building a new conceptual framework for receptor heteromers

Journal article published in 2009 by Sergi Ferré, Ruben Baler, Michel Bouvier ORCID, Marc G. Caron, Lakshmi A. Devi, Thierry Durroux, Kjell Fuxe, Susan R. George, Jonathan A. Javitch, Martin J. Lohse, Ken Mackie, Graeme Milligan, Kevin D. G. Pfleger, Jean-Philippe Pin, Nora D. Volkow and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.