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First asymmetric synthesis of (2R, 3R)-3-amino-1-benzyl-2-methyl-pyrrolidine via a highly diastereoselective reductive alkylation

Journal article published in 1997 by Pei Qiang Huang ORCID, Si Li Wang, Hong Zheng, Xiang Su Fei
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

The first asymmetric synthesis of (2R, 3R)-3-amino-1-benzyl-2-methylpyrrolidine the parent diamine of antipsychotic agent, emonapride, from (S)-malic acid was achieved via a highly diastereroselective reductive alkylation. Copyright (C) 1996 Elsevier Science Ltd