Common variants associated with plasma triglycerides and risk for coronary artery disease

Do, Ron; Willer, Cristen J.; Schmidt, Ellen M.; Sengupta, Sebanti; Van Den Herik, Eg; Van den Herik, Evita G.; Gao, Chi; Peloso, Gina M.; Van Duijn, Cm; Gustafsson, Stefan; Kanoni, Stavroula; Ganna, Andrea; Chen, Jin; Buchkovich, Martin L.; Mora, Samia; Beckmann, Jacques S.; Bragg-Gresham, Jennifer L.; Chang, Hsing-Yi; Demirkan, Ayşe; Den Hertog, Heleen M.; Donnelly, Louise A.; Ehret, Georg B.; Esko, Tõnu; Feitosa, Mary F.; Ferreira, Teresa; Fischer, Krista; Fontanillas, Pierre; Van Pelt, Lj; Fraser, Ross M.; Freitag, Daniel F.; Gurdasani, Deepti; Heikkilä, Kauko; Hyppönen, Elina; Sanna, Serena; Isaacs, Aaron; Saxena, Richa; Jackson, Anne U.; Service, Susan K.; Johansson, Åsa; Shah, Sonia; Johnson, Toby; Kaakinen, Marika; Shungin, Dmitry; Kettunen, Johannes; Sidore, Carlo; Kleber, Marcus E.; Song, Ci; Li, Xiaohui; Strawbridge, Rona J.; Luan, Jian’an; Surakka, Ida; Lyytikäinen, Leo-Pekka; Magnusson, Patrik K. E.; Tanaka, Toshiko; Mangino, Massimo; Teslovich, Tanya M.; Mihailov, Evelin; Montasser, May E.; Thorleifsson, Gudmar; Müller-Nurasyid, Martina; Nolte, Ilja M.; Voight, Benjamin F.; O'Connell, Jeffrey R.; Palmer, Cameron D.; Volcik, Kelly A.; Perola, Markus; Waite, Lindsay Ll; Petersen, Ann-Kristin; Wong, Andrew; Wu, Ying; Zhang, Weihua; Johansson, Å.; Absher, Devin; Asiki, Gershim; Johansson, Åsa; Barroso, Inês; Been, Latonya F.; Bolton, Jennifer L.; Bonnycastle, Lori Ll; Brambilla, Paolo; Burnett, Mary S.; Cesana, Giancarlo; Dimitriou, Maria; Doney, Alex S. F.; Döring, Angela; Elliott, Paul; Epstein, Stephen E.; Hyppoenen, Elina; Eyjolfsson, Gudmundur Ingi; Gigante, Bruna; Goodarzi, Mark O.; Grallert, Harald; Gravito, Martha L.; Müller-Nurasyid, Martina; Groves, Christopher J.; Hallmans, Göran; Hartikainen, Anna-Liisa; Hayward, Caroline; Hernandez, Dena; Hicks, Andrew Aa; Holm, Hilma; Hung, Yi-Jen; Rader, Daniel J.; Illig, Thomas; Reilly, Muredach P.; Jones, Michelle R.; Kaleebu, Pontiano; Ridker, Paul M.; Kastelein, John J. P.; Rivadeneira, Fernando; Khaw, Kay-Tee; Rudan, Igor; Kim, Eric; Ruokonen, Aimo; Klopp, Norman; Samani, Nilesh; Komulainen, Pirjo; Scharnagl, Hubert; Kumari, Meena; Langenberg, Claudia; Seeley, Janet; O’connell, Jeffrey R.; Lehtimäki, Terho; Silander, Kaisa; Lin, Shih-Yi; Stančáková, Alena; Lindström, Jaana; Stirrups, Kathleen; Loos, Ruth J. F.; Swift, Amy J.; Mach, François; McArdle, Wendy L.; Tiret, Laurence; Meisinger, Christa; Uitterlinden, Andre G.; Mitchell, Braxton D.; Müller, Gabrielle; van Pelt, Lj Joost; Nagaraja, Ramaiah; Vedantam, Sailaja; Narisu, Narisu; Nieminen, Tuomo V. M.; Wainwright, Nicholas; Nsubuga, Rebecca N.; Olafsson, Isleifur; Wijmenga, Cisca; Ong, Ken Kk; Wild, Sarah H.; Palotie, Aarno; Mueller-Nurasyid, Martina; Willemsen, Gonneke; Papamarkou, Theodore; Wilsgaard, Tom; Pomilla, Cristina; Pouta, Anneli; Wilson, James F.; Young, Elizabeth H.; Zhao, Jing Hua; Doering, Angela; Adair, Linda S.; Arveiler, Dominique; Assimes, Themistocles L.; Bandinelli, Stefania; Bennett, Franklyn; Bochud, Murielle; Boehm, Bernhard O.; de Faire, Ulf; Boomsma, Dorret I.; Borecki, Ingrid B.; Bornstein, Stefan R.; Bovet, Pascal; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chambers, John C.; Chen, Yii-Der Ida; Mueller, Gabrielle; Collins, Francis S.; Cooper, Richard S.; Danesh, John; Dedoussis, George; Feranil, Alan B.; Ferrieres, Jean; Ferrucci, Luigi; Freimer, Nelson B.; Gieger, Christian; Groop, Leif C.; Gudnason, Vilmundur; Gyllensten, Ulf; Hamsten, Anders; Joost van Pelt, L.; Harris, Tamara B.; Hingorani, Aroon; Hirschhorn, Joel N.; Hofman, Albert; März, Winfried; Hovingh, Gk Kees; Psaty, Bruce M.; Hsiung, Chao Agnes; Quertermous, Thomas; Humphries, Steve E.; Rauramaa, Rainer; Hunt, Steven C.; De Faire, U.; Hveem, Kristian; Saleheen, Danish; Iribarren, Carlos; Salomaa, Veikko; Järvelin, Marjo-Riitta; Sanghera, Dharambir K.; Jula, Antti; Saramies, Jouko; Kähönen, Mika; Schwarz, Peter E. H.; Kaprio, Jaakko; Sheu, Wayne H.-H.; Kesäniemi, Antero; Shuldiner, Alan R.; Kivimaki, Mika; Kooner, Jaspal S.; Siegbahn, Agneta; Koudstaal, Peter J.; Spector, Tim D.; Krauss, Ronald M.; Kuh, Diana; Stefansson, Kari; Kuusisto, Johanna; Strachan, David P.; Kyvik, Kirsten O.; Laakso, Markku; Tayo, Bamidele O.; Lakka, Timo A.; Tremoli, Elena; Lind, Lars; Lindgren, Cecilia M.; Tuomilehto, Jaakko; Martin, Nicholas G.; März, Winfried; Uusitupa, Matti; McCarthy, Mark I.; van Duijn, Cornelia M.; Mckenzie, Colin A.; Vollenweider, Peter; Meneton, Pierre; Metspalu, Andres; Wallentin, Lars; Moilanen, Leena; Wareham, Nicholas J.; Morris, Andrew D.; Munroe, Patricia B.; Whitfield, John B.; Njølstad, Inger; Wolffenbuttel, Bruce H. R.; Kees Hovingh, G.; Pedersen, Nancy L.; Power, Chris and; Pramstaller, Peter Pp; Price, Jackie F.; Thorsteinsdottir, Unnur; Rotter, Jerome I.; Jarvelin, Marjo-Riitta; Ripatti, Samuli; Sandhu, Manjinder S.; Rich, Stephen Ss; Altshuler, David; Ordovas, Jose M.; Boerwinkle, Eric; Palmer, Colin N. A.; Kahonen, Mika; Chasman, Daniel I.; Maerz, Winfried; Franks, Paul W.; Cupples, La Adrienne; Boehnke, Michael; Deloukas, Panos; Mohlke, Karen L.; Ingelsson, Erik; Adrienne Cupples, L.; Abecasis, Gonçalo R.; Daly, Mark J.; Neale, Benjamin M.; Kathiresan, Sekar

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Ellen Schmidt
Do et al., 2013

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@article{Do2013,
  abstract = {Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P &lt; 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.},
  author = {Do, Ron and Willer, Cristen J. and Schmidt, Ellen M. and Sengupta, Sebanti and Van Den Herik, Eg and Van den Herik, Evita G. and Gao, Chi and Peloso, Gina M. and Van Duijn, Cm and Gustafsson, Stefan and Kanoni, Stavroula and Ganna, Andrea and Chen, Jin and Buchkovich, Martin L. and Mora, Samia and Beckmann, Jacques S. and Bragg-Gresham, Jennifer L. and Chang, Hsing-Yi and Demirkan, Ayşe and Den Hertog, Heleen M. and Donnelly, Louise A. and Ehret, Georg B. and Esko, Tõnu and Feitosa, Mary F. and Ferreira, Teresa and Fischer, Krista and Fontanillas, Pierre and Van Pelt, Lj and Fraser, Ross M. and Freitag, Daniel F. and Gurdasani, Deepti and Heikkilä, Kauko and Hyppönen, Elina and Sanna, Serena and Isaacs, Aaron and Saxena, Richa and Jackson, Anne U. and Service, Susan K. and Johansson, Åsa and Shah, Sonia and Johnson, Toby and Kaakinen, Marika and Shungin, Dmitry and Kettunen, Johannes and Sidore, Carlo and Kleber, Marcus E. and Song, Ci and Li, Xiaohui and Strawbridge, Rona J. and Luan, Jian’an and Surakka, Ida and Lyytikäinen, Leo-Pekka and Magnusson, Patrik K. E. and Tanaka, Toshiko and Mangino, Massimo and Teslovich, Tanya M. and Mihailov, Evelin and Montasser, May E. and Thorleifsson, Gudmar and Müller-Nurasyid, Martina and Nolte, Ilja M. and Voight, Benjamin F. and O'Connell, Jeffrey R. and Palmer, Cameron D. and Volcik, Kelly A. and Perola, Markus and Waite, Lindsay Ll and Petersen, Ann-Kristin and Wong, Andrew and Wu, Ying and Zhang, Weihua and Johansson, Å. and Absher, Devin and Asiki, Gershim and Johansson, Åsa and Barroso, Inês and Been, Latonya F. and Bolton, Jennifer L. and Bonnycastle, Lori Ll and Brambilla, Paolo and Burnett, Mary S. and Cesana, Giancarlo and Dimitriou, Maria and Doney, Alex S. F. and Döring, Angela and Elliott, Paul and Epstein, Stephen E. and Hyppoenen, Elina and Eyjolfsson, Gudmundur Ingi and Gigante, Bruna and Goodarzi, Mark O. and Grallert, Harald and Gravito, Martha L. and Müller-Nurasyid, Martina and Groves, Christopher J. and Hallmans, Göran and Hartikainen, Anna-Liisa and Hayward, Caroline and Hernandez, Dena and Hicks, Andrew Aa and Holm, Hilma and Hung, Yi-Jen and Rader, Daniel J. and Illig, Thomas and Reilly, Muredach P. and Jones, Michelle R. and Kaleebu, Pontiano and Ridker, Paul M. and Kastelein, John J. P. and Rivadeneira, Fernando and Khaw, Kay-Tee and Rudan, Igor and Kim, Eric and Ruokonen, Aimo and Klopp, Norman and Samani, Nilesh and Komulainen, Pirjo and Scharnagl, Hubert and Kumari, Meena and Langenberg, Claudia and Seeley, Janet and O’connell, Jeffrey R. and Lehtimäki, Terho and Silander, Kaisa and Lin, Shih-Yi and Stančáková, Alena and Lindström, Jaana and Stirrups, Kathleen and Loos, Ruth J. F. and Swift, Amy J. and Mach, François and McArdle, Wendy L. and Tiret, Laurence and Meisinger, Christa and Uitterlinden, Andre G. and Mitchell, Braxton D. and Müller, Gabrielle and van Pelt, Lj Joost and Nagaraja, Ramaiah and Vedantam, Sailaja and Narisu, Narisu and Nieminen, Tuomo V. M. and Wainwright, Nicholas and Nsubuga, Rebecca N. and Olafsson, Isleifur and Wijmenga, Cisca and Ong, Ken Kk and Wild, Sarah H. and Palotie, Aarno and Mueller-Nurasyid, Martina and Willemsen, Gonneke and Papamarkou, Theodore and Wilsgaard, Tom and Pomilla, Cristina and Pouta, Anneli and Wilson, James F. and Young, Elizabeth H. and Zhao, Jing Hua and Doering, Angela and Adair, Linda S. and Arveiler, Dominique and Assimes, Themistocles L. and Bandinelli, Stefania and Bennett, Franklyn and Bochud, Murielle and Boehm, Bernhard O. and de Faire, Ulf and Boomsma, Dorret I. and Borecki, Ingrid B. and Bornstein, Stefan R. and Bovet, Pascal and Burnier, Michel and Campbell, Harry and Chakravarti, Aravinda and Chambers, John C. and Chen, Yii-Der Ida and Mueller, Gabrielle and Collins, Francis S. and Cooper, Richard S. and Danesh, John and Dedoussis, George and Feranil, Alan B. and Ferrieres, Jean and Ferrucci, Luigi and Freimer, Nelson B. and Gieger, Christian and Groop, Leif C. and Gudnason, Vilmundur and Gyllensten, Ulf and Hamsten, Anders and Joost van Pelt, L. and Harris, Tamara B. and Hingorani, Aroon and Hirschhorn, Joel N. and Hofman, Albert and März, Winfried and Hovingh, Gk Kees and Psaty, Bruce M. and Hsiung, Chao Agnes and Quertermous, Thomas and Humphries, Steve E. and Rauramaa, Rainer and Hunt, Steven C. and De Faire, U. and Hveem, Kristian and Saleheen, Danish and Iribarren, Carlos and Salomaa, Veikko and Järvelin, Marjo-Riitta and Sanghera, Dharambir K. and Jula, Antti and Saramies, Jouko and Kähönen, Mika and Schwarz, Peter E. H. and Kaprio, Jaakko and Sheu, Wayne H.-H. and Kesäniemi, Antero and Shuldiner, Alan R. and Kivimaki, Mika and Kooner, Jaspal S. and Siegbahn, Agneta and Koudstaal, Peter J. and Spector, Tim D. and Krauss, Ronald M. and Kuh, Diana and Stefansson, Kari and Kuusisto, Johanna and Strachan, David P. and Kyvik, Kirsten O. and Laakso, Markku and Tayo, Bamidele O. and Lakka, Timo A. and Tremoli, Elena and Lind, Lars and Lindgren, Cecilia M. and Tuomilehto, Jaakko and Martin, Nicholas G. and März, Winfried and Uusitupa, Matti and McCarthy, Mark I. and van Duijn, Cornelia M. and Mckenzie, Colin A. and Vollenweider, Peter and Meneton, Pierre and Metspalu, Andres and Wallentin, Lars and Moilanen, Leena and Wareham, Nicholas J. and Morris, Andrew D. and Munroe, Patricia B. and Whitfield, John B. and Njølstad, Inger and Wolffenbuttel, Bruce H. R. and Kees Hovingh, G. and Pedersen, Nancy L. and Power, Chris and and Pramstaller, Peter Pp and Price, Jackie F. and Thorsteinsdottir, Unnur and Rotter, Jerome I. and Jarvelin, Marjo-Riitta and Ripatti, Samuli and Sandhu, Manjinder S. and Rich, Stephen Ss and Altshuler, David and Ordovas, Jose M. and Boerwinkle, Eric and Palmer, Colin N. A. and Kahonen, Mika and Chasman, Daniel I. and Maerz, Winfried and Franks, Paul W. and Cupples, La Adrienne and Boehnke, Michael and Deloukas, Panos and Mohlke, Karen L. and Ingelsson, Erik and Adrienne Cupples, L. and Abecasis, Gonçalo R. and Daly, Mark J. and Neale, Benjamin M. and Kathiresan, Sekar},
  doi = {10.1038/ng.2795},
  month = {oct},
  title = {Common variants associated with plasma triglycerides and risk for coronary artery disease},
  url = {http://ir.nhri.org.tw/bitstream/3990099045/7623/1/SCP84884846622.pdf},
  year = {2013}
}

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Common variants associated with plasma triglycerides and risk for coronary artery disease

Journal article published in 2013 by Ron Do, Cristen J. Willer, Ellen M. Schmidt

, Sebanti Sengupta, Eg Van Den Herik, Evita G. Van den Herik, Chi Gao, Gina M. Peloso, Cm Van Duijn, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna

, Jin Chen, Martin L. Buchkovich, Samia Mora and other authors. Ron Do, Cristen J. Willer, Ellen M. Schmidt

, Sebanti Sengupta, Eg Van Den Herik, Evita G. Van den Herik, Chi Gao, Gina M. Peloso, Cm Van Duijn, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna

, Jin Chen, Martin L. Buchkovich, Samia Mora, Jacques S. Beckmann

, Jennifer L. Bragg-Gresham, Hsing-Yi Chang, Ayşe Demirkan

, Heleen M. Den Hertog, Louise A. Donnelly, Georg B. Ehret, Tõnu Esko

, Mary F. Feitosa, Teresa Ferreira, Krista Fischer, Pierre Fontanillas, Lj Van Pelt, Ross M. Fraser, Daniel F. Freitag, Deepti Gurdasani

, Kauko Heikkilä, Elina Hyppönen

, Serena Sanna

, Aaron Isaacs, Richa Saxena, Anne U. Jackson, Susan K. Service, Åsa Johansson, Sonia Shah, Toby Johnson

, Marika Kaakinen

, Dmitry Shungin, Johannes Kettunen, Carlo Sidore

, Marcus E. Kleber, Ci Song, Xiaohui Li, Rona J. Strawbridge, Jian’an Luan, Ida Surakka, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Toshiko Tanaka, Massimo Mangino, Tanya M. Teslovich, Evelin Mihailov, May E. Montasser, Gudmar Thorleifsson, Martina Müller-Nurasyid, Ilja M. Nolte, Benjamin F. Voight, Jeffrey R. O'Connell, Cameron D. Palmer, Kelly A. Volcik, Markus Perola, Lindsay Ll Waite, Ann-Kristin Petersen, Andrew Wong, Ying Wu, Weihua Zhang, Å. Johansson, Devin Absher, Gershim Asiki, Åsa Johansson, Inês Barroso, Latonya F. Been, Jennifer L. Bolton, Lori Ll Bonnycastle, Paolo Brambilla, Mary S. Burnett, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Döring, Paul Elliott, Stephen E. Epstein, Elina Hyppoenen, Gudmundur Ingi Eyjolfsson, Bruna Gigante

, Mark O. Goodarzi, Harald Grallert, Martha L. Gravito, Martina Müller-Nurasyid, Christopher J. Groves, Göran Hallmans, Anna-Liisa Hartikainen, Caroline Hayward, Dena Hernandez, Andrew Aa Hicks, Hilma Holm, Yi-Jen Hung, Daniel J. Rader, Thomas Illig, Muredach P. Reilly, Michelle R. Jones, Pontiano Kaleebu, Paul M. Ridker, John J. P. Kastelein, Fernando Rivadeneira, Kay-Tee Khaw, Igor Rudan, Eric Kim, Aimo Ruokonen, Norman Klopp, Nilesh Samani, Pirjo Komulainen, Hubert Scharnagl, Meena Kumari

, Claudia Langenberg, Janet Seeley, Jeffrey R. O’connell, Terho Lehtimäki, Kaisa Silander, Shih-Yi Lin, Alena Stančáková, Jaana Lindström

, Kathleen Stirrups, Ruth J. F. Loos, Amy J. Swift, François Mach, Wendy L. McArdle, Laurence Tiret, Christa Meisinger

, Andre G. Uitterlinden, Braxton D. Mitchell, Gabrielle Müller, Lj Joost van Pelt, Ramaiah Nagaraja, Sailaja Vedantam, Narisu Narisu, Tuomo V. M. Nieminen, Nicholas Wainwright, Rebecca N. Nsubuga, Isleifur Olafsson, Cisca Wijmenga

, Ken Kk Ong, Sarah H. Wild, Aarno Palotie, Martina Mueller-Nurasyid, Gonneke Willemsen, Theodore Papamarkou, Tom Wilsgaard, Cristina Pomilla, Anneli Pouta, James F. Wilson, Elizabeth H. Young, Jing Hua Zhao, Angela Doering, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn Bennett, Murielle Bochud, Bernhard O. Boehm, Ulf de Faire, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet

, Michel Burnier, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Yii-Der Ida Chen, Gabrielle Mueller, Francis S. Collins, Richard S. Cooper, John Danesh, George Dedoussis, Alan B. Feranil, Jean Ferrieres, Luigi Ferrucci, Nelson B. Freimer, Christian Gieger

, Leif C. Groop, Vilmundur Gudnason, Ulf Gyllensten, Anders Hamsten, L. Joost van Pelt, Tamara B. Harris, Aroon Hingorani, Joel N. Hirschhorn, Albert Hofman, Winfried März, Gk Kees Hovingh, Bruce M. Psaty, Chao Agnes Hsiung, Thomas Quertermous, Steve E. Humphries, Rainer Rauramaa, Steven C. Hunt, U. De Faire, Kristian Hveem, Danish Saleheen, Carlos Iribarren, Veikko Salomaa, Marjo-Riitta Järvelin, Dharambir K. Sanghera, Antti Jula, Jouko Saramies, Mika Kähönen

, Peter E. H. Schwarz, Jaakko Kaprio, Wayne H.-H. Sheu, Antero Kesäniemi, Alan R. Shuldiner, Mika Kivimaki

, Jaspal S. Kooner, Agneta Siegbahn, Peter J. Koudstaal, Tim D. Spector, Ronald M. Krauss, Diana Kuh, Kari Stefansson, Johanna Kuusisto, David P. Strachan, Kirsten O. Kyvik, Markku Laakso, Bamidele O. Tayo, Timo A. Lakka, Elena Tremoli, Lars Lind, Cecilia M. Lindgren, Jaakko Tuomilehto, Nicholas G. Martin

, Winfried März, Matti Uusitupa, Mark I. McCarthy, Cornelia M. van Duijn, Colin A. Mckenzie, Peter Vollenweider, Pierre Meneton, Andres Metspalu, Lars Wallentin, Leena Moilanen, Nicholas J. Wareham, Andrew D. Morris, Patricia B. Munroe, John B. Whitfield, Inger Njølstad, Bruce H. R. Wolffenbuttel, G. Kees Hovingh, Nancy L. Pedersen, Chris and Power, Peter Pp Pramstaller

, Jackie F. Price

, Unnur Thorsteinsdottir, Jerome I. Rotter, Marjo-Riitta Jarvelin, Samuli Ripatti, Manjinder S. Sandhu, Stephen Ss Rich, David Altshuler, Jose M. Ordovas, Eric Boerwinkle, Colin N. A. Palmer, Mika Kahonen, Daniel I. Chasman, Winfried Maerz, Paul W. Franks, La Adrienne Cupples

, Michael Boehnke, Panos Deloukas, Karen L. Mohlke, Erik Ingelsson, L. Adrienne Cupples, Gonçalo R. Abecasis, Mark J. Daly, Benjamin M. Neale, Sekar Kathiresan

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Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

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Common variants associated with plasma triglycerides and risk for coronary artery disease

Abstract