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Elsevier, Tetrahedron, 5(61), p. 1335-1344, 2005

DOI: 10.1016/j.tet.2004.10.109

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Studies on the diastereoselective reductive alkylation of (R)-phenylglycinol derived phthalimide: observation of stereoelectronic effects

Journal article published in 2004 by Ming De Chen, 阮源萍, 黄培强, Ming-Zhu He, Xiang Zhou, Li-Qiang Huang, Yuan-Ping Ruan, Pei-Qiang Huang ORCID
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Abstract

Full details of a flexible approach to N-protected (R)-3-alkyl-isoindolin-1-ones 13 via diastereoselective reductive-alkylation are described, with emphasis on the stereochemical outcome of the key diastereoselective reactions. Additional experiments allowed finding remarkable stereoelectronic effects on the reductive ring-opening reactions. (C) 2004 Elsevier Ltd. All rights reserved.