Published in
Wiley, Angewandte Chemie International Edition, 17(49), p. 3037-3040, 2010
Wiley, Angewandte Chemie, 17(122), p. 3101-3104, 2010
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Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation
Journal article published in 2010 by
Kai-Jiong; Luo Jie-Min Xiao 
,
黄培强,
Jie-Min Luo,
Ke-Yin Ye,
Yu Wang,
Pei-Qiang Huang
,
黄培强,
Jie-Min Luo,
Ke-Yin Ye,
Yu Wang,
Pei-Qiang Huang
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Abstract
(Figure Presented) Be dazzled by the sequence: The first efficient and general one-pot method for the reductive bisalkylation of lactams/ amides with Grignard and organolithium reagents has been developed (see scheme; DTBMP = 2,6-di-tert-butyl-4methylpyridine, Tf=trifluoromethanesulfonyl).